WHAT IS
DUCHENNE MUSCULAR
DYSTROPHY?

DUCHENNE IS A RARE DISEASE CAUSED BY A GENETIC MUTATION

Duchenne muscular dystrophy (DMD) is a disorder in which people are born with a genetic mutation that leads to an absence of or a defect in dystrophin, a protein that protects muscles from damage.

This the group background image

Dystrophin is a protein found in muscles that works with other proteins to make sure muscles are protected from injury as they expand and contract

BOYS ARE MORE LIKELY TO BE AFFECTED BY DUCHENNE THAN GIRLS

The gene that carries a Duchenne-causing mutation is found on the X chromosome. Every boy inherits an X chromosome from his mother and a Y chromosome from his father, which is what makes him male, as opposed to girls who get two X chromosomes, one from each parent.

Since girls have two X chromosomes, even if one of the chromosomes is affected by the dystrophin mutation that causes Duchenne, they may still have a healthy gene from the other parent. Girls who have one X chromosome affected by a dystrophin mutation but do not have Duchenne symptoms are known as Duchenne carriers, and they can pass the mutation on to their children.

Duchenne affects up to 1 in 3600 to 6000 male births